“Play Clean” is the name of a Pepsi Center program that encourages fans to recycle products used during concerts and events, as well as reduce pollution caused by cars. Launched in 2008, the program was developed specifically for the Pepsi Center and the teams that call the Pepsi Center it's home (the Colorado Avalanche, Denver Nuggets, and Colorado Mammoth).

When launched, the Pepsi Center became the first major entertainment venue in Colorado to provide single-stream recycling of plastic cups, all bottles, and clean paper products used during events. Items being placed in recycling bins on arena concourse started with the Men's NCAA basketball tournament in March 2008.

Other efforts to protect the environment have been implemented since the “Play Clean” program started and new initiatives are constantly being evaluated. For example, a limited number of preferred spaces in Pepsi Center's parking lots are now designated for hybrid cars. The parking fees remain the same as standard spaces and are available on a first-come, first-served basis.

In October 2019, the Pepsi Center announced that it would be the first major professional sports arena to use single use aluminum cups on a large-scale basis in connection with its concession sales. The Pepsi Center worked with Ball Corp., the producer of the infinitely recyclable aluminum cups, as part of a pilot program. The cups made their debut at the Pepsi Center with the Denver Nuggets game against the Phoenix Suns on October 25, 2019.